ORGANIC CHEMISTRY
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1.
IUPAC nomenclature of organic compounds.
2.
Principles of stereochemistry, conformational analysis, isomerism and
chirality.
3.
Reactive intermediates and organic reaction mechanisms.
4.
Concepts of aromaticity.
5.
Pericyclic reactions.
6.
Named reactions.
7.
Transformations and rearrangements.
8.
Principles and applications of organic photochemistry. Free radical
reactions.
9.
Reactions involving nucleophotic carbon intermediates.
11.
Common reagents (organic, inorganic and organometallic) in organic synthesis.
12.
Chemistry of natural products such as steroids, alkaloids, terpenes,
peptides, carbohydrates, nucleic acids and lipids.
13.
Selective organic transformations – chemoselectivity, regioselectivity,
stereoselectivity, enantioselectivity. Protecting groups.
14.
Chemistry of aromatic and aliphatic heterocyclic compounds.
15. Physical characterisation of organic compounds by IR, UV-,
MS, and NMR.
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ORGANIC CHEMISTRY
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1.
Aromaticity : Huckel’s rule and concept of
aromaticity : annulenes and heteroannulenes, fullerenes. (C ) Stereochemistry
and Conformational Analysis : Newer methods of assymetric synthesis
(including enzymatic and catalytic nexus), enantio-and diastereo selective
synthesis. Effects of conformation on reactivity in acylic compounds and
cyclohexanes.
2.
Selective Organic Name Reactions : Favorskii reaction, Strok enamine reaction,
3.
Michael addition, Mannich reaction, Sharpless asymmetric expoxidation,
ene reaction,
4.
Barton reaction, Hofmann Loffler-Freytag reaction, Shapiro reaction,
Baeyer-Villiger
5.
reaction, Chichibabin reaction.
6.
Mechanisms of Organic Reactions : Labelling
and kinetic isotope effects, Hamett
7.
equation, a-5 (sigma-rho) relationship, non-classical carbonium
ions, neighbouring
8.
group participation.
9.
Pericyclic Reactions : Selection rules and
stereochemistry of electrocyclic reactions, cycloaddition and sigmatrophic
shifts, Sommelet-Hauser, Cope and Claisen rearrangements.
10.
Heterocycles : Synthesis and reactivity of
furan, thiophene, pyrrole, pyridine, quinoline, isoquinoline and indole.
Skraup synthesis, Fischer indole synthesis.
11.
Reagents in Organic Synthesis : Use of
following reagents in organic synthesis and fuctinal group
transformations-Complex metal hydride. Gilman’s reagent, lithium,
dimethylcuprate, lithim, disopropylamide (LDA) dicyclohexylcarbodimide, 1,
3-dithiane (reactivity umpolung). Trimethy, silyl iodide, tri-n-butyltin
hydride, Woodward and Prevost hydroxylation, osmium tetraoxide, DDQ, selenium
dioxide, phase transfer catalysts, crown ethers and Merrifield resin.
Peterson’s synthesis, Wilkinson’s catalyst, Baker’s yeast.
12.
Chemistry of Natural Products : Familiarity
with methods of structure elucidation and biosynthesis of alkaloids,
terpenoids, steroids, carbohydrates and proteins, Conformations of proteins
and nucleic acids.
13.
Bioorganic Chemistry : Elementary structure
and function of biopolymers such as proteins and nucleic acids, Genetic code,
Mechanism of enzyme action.
14.
Photochemistry : Principles of energy
transfer, cis-trans isomerization, Paterno-Buchi reaction, Norrish Type I and
II reactions, photoreduction of ketones, di-pi-methane rearrangement,
photochemistry of arenes.
15.
Spectroscopy : Combined applications of mass,
UV-VIS, IR and NMR spectroscopy for structural elucidation of compounds.
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ORGANIC CHEMISTRY
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1.
Stereochemistry: Chirality of organic
molecules with or without chiral centres. Specification of configuration in
compounds having one or more stereogeniccentres. Enantiotopic and diastereotopic
atoms, groups and faces. Stereoselective and stereospecific synthesis. Conformational
analysis of acyclic and cyclic compounds. Geometrical isomerism. Configurational
and conformational effects on reactivity and selectivity/specificity.
2.
Reaction mechanism: Methods of determining
reaction mechanisms. Nucleophilic and electrophilic substitutions and
additions to multiple bonds. Elimination reactions. Reactive intermediates-
carbocations, carbanions, carbenes, nitrenes, arynes, free radicals. Molecular
rearrangements involving electron deficient atoms.
3.
Organic synthesis: Synthesis, reactions,
mechanisms and selectivity involving the ollowingalkenes, alkynes, arenes, alcohols,
phenols, aldehydes, ketones, carboxylic acids and their derivatives, halides,
nitro compounds and amines. Use of compounds of Mg, Li, Cu, B and Si in organic
synthesis. Concepts in multistep synthesis- retrosynthetic analysis,
disconnections, synthons, synthetic equivalents, reactivity umpolung,
selectivity, protection and deprotection of functional groups.
4.
Pericyclic reactions: Electrocyclic,
cycloaddition and sigmatropic reactions. Orbital correlation, FMO and PMO treatments.
5.
Photochemistry: Basic principles.
Photochemistry of alkenes, carbonyl compounds, and arenes. Photooxidation and
photoreduction. Di-π- methane rearrangement, Barton reaction.
6.
Heterocyclic compounds: Structure,
preparation, properties and reactions of furan, pyrrole, thiophene, pyridine,
indole and their derivatives.
7.
Biomolecules: Structure, properties and
reactions of mono- and di-saccharides, physicochemical properties of amino
acids, chemical synthesis of peptides, structural features of proteins,
nucleic acids, steroids, terpenoids, carotenoids, and alkaloids.
8.
Spectroscopy: Principles and applications of
UV-visible, IR, NMR and Mass spectrometry in the determination of structures
of organic molecules.
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ORGANIC CHEMISTRY
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1.
Aromaticity : Huckel's rule and concept of
aromaticty (n) annulenes and heteroannulenes, fiillerenes (C60)
2.
Stereochemistry and conformational Analysis :
Nwere method of asymmetric synthesis (including enzymatic and catalytic
nexus), enantio and diastereo selective synthesis. Effects of conformation
on reactivity in acyclic compounds and cyclohexanes.
3.
Selective Organic Name Reactions : Favorskil
reaction; Stork enamine reaction; Michael addition; Sharpless asymmetric
epoxidaton; Ene reaction, Barton reaction, Hofmann-Loffler- Freytag reaction,
Shapiro reaction, Baeyer-Villiger reaction, Chichibabin reaction.
4.
Mechanisms of Organic Reaction : Labelling and
Kinetio isotope effects, Hamett equation, (sigma-rho) relationship, non-classical
carbonium ions, neighbouring group participation.
5.
Pericyclic Reactions : Selection rules and
stereochemistry of electrocyclic reactions, cycloaddition and sigmatropic
shifts, Sommelet, Hauser, Cope and Claisen rearrangements.
6.
Heterocyclic Chemistry : Synthesis and
reactivity of furan thiophene, pyrrole, pyridine, quinoline, isoquinoline and
indole; Skraup synthesis, fischer indole synthesis.
7.
Reagents in Organic Synthesis : Use of the
following reagents in organic synthesis and functional group transformations;
Complex metal hybrides, Gilmen's reagent, lithium dimethylcuprate, lithium
disopropylamide (LDS\A) dicyclohexyicarbodimide, 1,3-dithiane (reactivity
umpolung), trimethylisilyl iodide, tri-n- butyltin hybride, Woodward and
prevost hydroxylation, osmium tetroxide, DDZ, selenium dioxide, phase
transfer catalysis, crown ethers and Merrifield resin, Peterson's synthesis,
Wilkinsons catalyst, Baker yeast.
8.
Chemistry of Natural products : Familiarity
with methods of structure elucidation and biosynthesis of alkaloids,
terponoids, steroids, carbohydrates and protains.
9.
Bioorganic Chemistry : Elementary structure
and function of biopolymers such as proteins and nucleic acids.
10.
3 3. Photochemistry : Cis-trans isomeriation,
Patemo-Buchi reaction, Norrish Type I and II reactions, photoreduction of
ketones, dipin ethane rearrangement, photochemistry of areanes.
11. 34.
Spectroscopy : Applications of mass, UV-VIS, IR and NMR spectroscopy for
structural elucidation of compound.
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